When I evaluate 2-(thiophen-2-yl)phenol, CAS 106584-13-8 for procurement, I treat it as a specialty aromatic building block rather than a finished pharmaceutical ingredient. Its listed molecular formula is C10H8OS, and its calculated molecular weight is approximately 176.24 g/mol. The compound combines a phenolic hydroxyl group with a thiophene ring, making it potentially useful for research, medicinal chemistry, and the preparation of more complex organic intermediates.
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A reliable buying decision should not rely on the name and CAS number alone. I recommend confirming identity, assay, impurity profile, physical form, packaging, documentation, and shipping requirements before placing an order. Because public product records may not provide a complete or consistent specification, the supplier’s current certificate of analysis remains the controlling document for each lot.
I prepared this guide for pharmaceutical and chemical manufacturers, research organizations, process-development teams, procurement managers, and distributors sourcing 2-(thiophen-2-yl)phenol. It is especially relevant when the material will be used as a starting material, synthetic intermediate, screening compound, or route-development input. Buyers who need a validated production-grade specification should use this overview as a purchasing framework, not as a substitute for technical qualification.
The guide is also useful for comparing suppliers that offer different grades, package sizes, analytical documents, or production routes. In practice, a lower quoted price may not represent a lower total cost if additional testing, repacking, or impurity investigation is required. I therefore recommend evaluating technical fit and supply reliability alongside the unit price.
2-(Thiophen-2-yl)phenol is an aromatic compound containing a phenol ring connected to a thiophene ring. The phenolic hydroxyl group can influence polarity, hydrogen bonding, and downstream chemical reactivity, while the sulfur-containing heteroaromatic ring provides a distinct structural motif for organic synthesis. Its identity should be verified using the CAS number, chemical name, molecular formula, molecular weight, and analytical data rather than by relying on a trade name alone.
The compound’s molecular formula is C10H8OS, with a calculated molecular weight of about 176.24 g/mol. These are useful reference points for theoretical calculations, solution preparation, stoichiometric planning, and analytical method development. They do not, by themselves, confirm purity, residual solvents, water content, or batch consistency.
I would normally consider this material for laboratory synthesis, medicinal chemistry programs, heteroaromatic compound development, and intermediate production where the structure is relevant to the target route. Its exact suitability depends on the reaction conditions, required impurity limits, scale, and final application. A supplier should not assume that a research-grade material automatically meets the requirements of a regulated manufacturing process.
Potential applications may include the preparation of substituted aromatic compounds, exploratory structure-activity relationship work, and route screening. These applications are best described as possible uses rather than guaranteed performance claims. Before scale-up, I recommend confirming reactivity, solubility, stability, and impurity behavior under the buyer’s actual process conditions.
R&D material is commonly selected for early-stage experiments, analytical method development, and reaction screening. Buyers may prioritize availability, small packaging, and basic identity data, while accepting that the documentation package may be less extensive than for manufacturing supply. Even at this stage, I recommend requesting a lot-specific COA and confirming the stated assay method.
For process development and commercial manufacturing, the buyer generally needs more than a nominal assay value. Important considerations may include a defined impurity profile, residual solvent information, water content, elemental impurities where relevant, batch traceability, packaging controls, and change-notification expectations. The exact specification should be agreed in writing before production or purchase.
A buyer may also request a custom specification when a particular impurity, solvent, color, particle size, or analytical method is critical to the process. I recommend distinguishing between a standard catalog specification and a contract specification so that both parties understand which tests are routine and which require additional development or validation.
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| Specification Area | What I Recommend Checking | Why It Matters |
|---|---|---|
| Identity | CAS 106584-13-8, name, formula, molecular weight, and suitable spectral data | Confirms that the supplied material matches the requested chemical |
| Assay | Reported value, analytical method, and acceptance criterion | Supports stoichiometric calculations and process consistency |
| Impurities | Known, unknown, and total impurity reporting where applicable | Helps assess downstream reaction and regulatory risk |
| Physical form | Appearance, solid or liquid description, and handling conditions | Supports storage, dispensing, and process planning |
| Documentation | COA, SDS, batch number, retest or review information, and packing record | Improves traceability and internal qualification |
I would avoid inserting an unverified melting point, storage life, or purity value into a purchase specification. These details can vary by lot, analytical method, packaging, and supplier process. If a project requires a specific acceptance limit, I recommend asking Maison Chemical to confirm whether the limit is routinely achieved and whether supporting testing can be included.
First, I identify whether the material is intended for discovery research, process development, analytical reference work, or manufacturing. This determines the required documentation, batch size, testing depth, and change-control expectations. It also prevents buyers from overpaying for documentation that is unnecessary for an early screening project or under-specifying material for a regulated process.
Next, I send the supplier a clear inquiry that includes the CAS number, required quantity, target assay, packaging preference, destination, and intended use. I also ask whether the quoted material is a standard product or a made-to-order batch. This distinction can affect lead time, minimum order quantity, testing arrangements, and the possibility of a pre-shipment sample.
I review the representative COA, SDS, analytical method, and available batch information before approving the order. If the supplier provides only a generic specification sheet, I request clarification on whether the data represent an actual batch or a general product standard. For a new supplier, a small qualification order or sample evaluation may reduce risk before a larger purchase.
Finally, I confirm packaging material, labeling, transport classification, storage recommendations, export documents, and delivery terms. Lead time should be quoted in writing because stock availability and production scheduling can change. I also ask how the supplier handles deviations, damaged packaging, out-of-specification results, and future specification changes.
The price of 2-(thiophen-2-yl)phenol can depend on quantity, grade, assay requirement, testing package, packaging, synthesis route, and destination. I would not treat a single online price as a dependable market benchmark because specialty chemical quotations are often project-specific. The most useful comparison is a landed-cost comparison that includes material, testing, freight, customs handling, and any repacking requirements.
Minimum order quantity may differ between stocked laboratory packs and production-oriented supply. Lead time may also range from immediate dispatch for available stock to several weeks for scheduled synthesis, although the actual commitment must come from the supplier’s quotation. I recommend requesting both a sample option and a commercial-quantity quotation when the project is still being qualified.
At Maison Chemical, I approach this type of inquiry by first clarifying the buyer’s application, quantity, quality target, and documentation needs. We can discuss standard supply, packaging options, analytical documentation, and whether a customized specification is technically appropriate. Any proposed value should be confirmed through a formal quotation and lot-specific documentation rather than assumed from a general product description.
For buyers comparing multiple sources, I recommend sending the same technical request to each supplier. Maison Chemical can then respond against defined requirements for identity, assay, impurity reporting, packaging, and delivery. This creates a more transparent basis for supplier evaluation and helps identify whether the main difference is price, documentation, production capability, or service scope.
My recommendation is to purchase 2-(thiophen-2-yl)phenol CAS 106584-13-8 only after matching the supplier’s actual specification to the intended use. For early research, identity confirmation and fit-for-purpose assay data may be sufficient, while process development and manufacturing generally require stronger impurity, traceability, and documentation controls. The correct grade is therefore determined by the project’s risk level, not by the chemical name alone.
As a next step, prepare an inquiry stating your required quantity, target specification, application, destination, packaging preference, and documentation requirements. Maison Chemical can use those details to assess supply feasibility and provide a more relevant quotation. Contact our chemicals team for a product discussion, sample request, or supplier specification review for 2-(thiophen-2-yl)phenol.
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