I identify 4-benzyloxy-2-methylphenylboronic acid, CAS 847560-49-0, as an aryl boronic acid building block for research and synthetic development. Its molecular formula is commonly represented as C14H15BO3, with a calculated molecular weight of approximately 242.08 g/mol. The molecule combines a boronic acid group with a benzyloxy substituent and a methyl group, making it relevant to medicinal chemistry, pharmaceutical intermediate development, and other laboratory-scale organic synthesis programs.
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At Maison Chemical, I recommend evaluating this product through more than its name and CAS number. Buyers should confirm identity, assay, water content, residual solvents, appearance, packaging, storage instructions, and batch-specific analytical documentation before placing an order. Because commercial specifications can vary by supplier and grade, the final certificate of analysis should control purchasing and release decisions.
This guide is intended for procurement teams, process chemists, medicinal chemistry researchers, custom synthesis companies, and distributors sourcing 4-benzyloxy-2-methylphenylboronic acid. It is particularly useful when a buyer needs to compare material from multiple suppliers or determine whether a catalog-grade product is suitable for a specific reaction sequence. I also recommend using this information as a technical discussion framework rather than as a replacement for project-specific laboratory validation.
The compound may be relevant to organizations developing substituted biaryl structures, protected phenol derivatives, or advanced intermediates. However, the appropriate grade, quantity, and documentation depend on the intended reaction, development stage, and internal quality system. A material suitable for route scouting may not automatically meet the requirements of process development or regulated manufacturing.
4-Benzyloxy-2-methylphenylboronic acid contains an aryl boronic acid functionality. In organic synthesis, aryl boronic acids are frequently considered partners for palladium-catalyzed Suzuki–Miyaura coupling, where the boron-containing aryl group can be transferred to a suitable electrophilic coupling partner under an appropriate reaction system. The benzyloxy group can also serve as a protected oxygen-containing substituent, while the methyl group changes the electronic and steric environment of the aromatic ring.
These structural features create potential value in the preparation of substituted aromatic compounds. They do not, however, guarantee a particular yield, selectivity, or reaction rate. I advise chemists to verify compatibility with the selected catalyst, base, solvent, temperature, atmosphere, and electrophile through small-scale experiments before making larger purchasing commitments.
| Item | Reference information | Buyer note |
|---|---|---|
| Product name | 4-Benzyloxy-2-methylphenylboronic acid | Confirm the name against the supplier’s structure and CAS record |
| CAS number | 847560-49-0 | Use CAS and structure together for identity verification |
| Molecular formula | C14H15BO3 | Check the formula on the batch documentation |
| Calculated molecular weight | Approximately 242.08 g/mol | Useful for reaction calculations and analytical method setup |
Suppliers may offer this type of boronic acid in different quantity levels and documentation packages rather than in fundamentally different chemical forms. Common purchasing categories can include small research quantities, gram-scale development quantities, and larger project-specific batches. I suggest treating “research grade” or similar wording as a starting description only, because the actual acceptance criteria should be defined by the certificate of analysis and your purchase specification.
For early screening, a buyer may prioritize availability, identity confirmation, and an assay appropriate for exploratory chemistry. For route development, the decision usually requires additional attention to impurity profile, lot consistency, water content, residual solvents, and reproducible packaging. If the product will enter a controlled manufacturing process, the buyer should discuss change notification, traceability, documentation, and quality agreements before approval.
In medicinal chemistry, this compound may be used as an aromatic building block for assembling analog libraries or preparing specifically substituted biaryl targets. The boronic acid group offers a practical functional handle for coupling studies, while the benzyloxy substituent can preserve an oxygen-related structural motif during selected synthetic steps. The actual suitability depends on the target structure and the stability of the compound under the planned reaction conditions.
Process and intermediate development teams may evaluate 4-benzyloxy-2-methylphenylboronic acid when a protected aromatic oxygen function is required in a multistep synthesis. In this setting, I recommend evaluating not only conversion but also isolation behavior, impurity purge, filtration, drying, and downstream stability. A route that works at milligram scale may require different solvent, base, or work-up choices at larger scale.
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Custom synthesis organizations may use the material as a starting point for producing more advanced aromatic intermediates. Analytical laboratories may also purchase it as a research reference material, provided that the intended use and documentation requirements are clearly defined. I would not assume that a standard commercial batch is automatically a certified reference standard unless the supplier explicitly provides the relevant certification.
I begin with the complete chemical name, CAS number, molecular formula, molecular weight, and structural representation. Buyers should check whether the supplier’s documentation clearly distinguishes the requested benzyloxy and methyl substitution pattern from positional isomers. Where the project is sensitive to isomeric impurities, request appropriate spectroscopic or chromatographic evidence before approval.
Assay is important, but it is not the only purchasing criterion. The buyer should specify acceptable limits for relevant impurities, water, residual solvents, and any known degradation products when those parameters affect the reaction or downstream step. I recommend requesting a representative certificate of analysis and confirming which results are batch-specific rather than generic product information.
Boronic acids can require careful handling because moisture, heat, and prolonged storage may affect material quality depending on the molecular structure and packaging system. The supplier should state the recommended container, storage temperature, protection from light or moisture where applicable, and retest or shelf-life policy. If a supplier recommends refrigerated storage, the buyer should confirm transport conditions and temperature-control responsibilities before shipment.
Price should be assessed together with minimum order quantity, available stock, lead time, packaging size, payment terms, and documentation support. A lower unit price may not be advantageous if the batch is unavailable when the project needs it or if additional testing is required after receipt. I advise buyers to obtain a written quotation that identifies the exact CAS number, grade, quantity, package configuration, delivery point, and validity period.
Pricing for specialty boronic acids is project-dependent and can change with batch size, raw material availability, analytical requirements, and production scheduling. I do not recommend relying on a universal price expectation without a current quotation. Small quantities often carry higher unit costs, while larger quantities may require production planning, quality review, and a mutually agreed specification.
Minimum order quantities should be matched to the customer’s actual consumption and stability information. For a discovery project, a smaller package can reduce inventory exposure, whereas a process program may need a reserved batch or staged delivery. Lead time should be confirmed in writing because “available” may refer to stock subject to quality release, while a new production batch may require additional manufacturing and testing time.
At Maison Chemical, I support buyers by clarifying product identity, quantity requirements, documentation expectations, and delivery planning for specialty organic boronic acids. Our role is to help customers evaluate a material against their application rather than make unsupported claims about universal performance. For a technical quotation, provide the required quantity, target grade, application stage, destination, and any analytical or packaging requirements.
4-Benzyloxy-2-methylphenylboronic acid CAS 847560-49-0 is a defined aryl boronic acid building block with a calculated molecular weight of approximately 242.08 g/mol and potential use in substituted aromatic synthesis. Its value comes from the combination of a coupling-capable boronic acid group, a benzyloxy substituent, and a methyl-substituted aromatic framework. Its practical performance must still be confirmed under the buyer’s specific reaction and quality conditions.
The best purchasing decision starts with structure verification, batch-specific analytical documentation, clear storage requirements, and a realistic assessment of MOQ and lead time. Contact Maison Chemical with your quantity, specification, and delivery requirements so I can help you review a suitable supply option and prepare a focused B2B quotation.
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