3-(Hydroxymethyl)phenylboronic acid, identified by CAS No. 87199-15-3, is an aromatic boronic acid containing both a boronic acid group and a hydroxymethyl group. Its molecular formula is commonly represented as C7H9BO3, with a calculated molecular weight of approximately 151.96 g/mol. I position this compound primarily as a research and pharmaceutical intermediate for carbon–carbon bond formation, especially Suzuki-type coupling, while its hydroxymethyl group provides an additional handle for downstream functionalization.
The molecule combines a phenyl ring with two useful functional features: an aryl boronic acid and a benzyl alcohol-type hydroxymethyl substituent. The boronic acid group can participate in palladium-catalyzed cross-coupling with suitable aryl or heteroaryl halides, while the hydroxymethyl group may be converted into ethers, esters, aldehydes, or other derivatives under appropriate reaction conditions. This dual functionality makes the compound relevant to building-block strategies in medicinal chemistry and specialty synthesis.
| Property | Information |
|---|---|
| Product name | 3-(Hydroxymethyl)phenylboronic acid |
| CAS number | 87199-15-3 |
| Molecular formula | C7H9BO3 |
| Approximate molecular weight | 151.96 g/mol |
| Functional groups | Aryl boronic acid and hydroxymethyl group |
The reported molecular weight is useful for reaction planning, solution preparation, and analytical method development, but buyers should confirm the value and product form on the supplier’s current specification sheet. Boronic acids can show differences in hydration, solid form, residual solvents, or assay depending on manufacturing and packaging conditions. For that reason, I recommend evaluating the lot-specific certificate of analysis rather than relying only on a catalog description.
The most recognizable synthetic role of 3-(Hydroxymethyl)phenylboronic acid is as an aryl boronic acid coupling partner. In a Suzuki–Miyaura reaction, the boronic acid functionality can be used to introduce a substituted phenyl group into a larger molecular framework. The actual conversion depends on the reaction partner, catalyst, base, solvent, temperature, and substrate stability, so I treat the compound as a versatile intermediate rather than a guaranteed solution for every coupling system.
The hydroxymethyl group gives chemists an additional site for selective modification. It may support preparation of protected alcohols, linkers, esters, ethers, or oxidation products, depending on the intended route and reaction compatibility. In route design, this can help researchers construct molecules that require both aromatic substitution and a second functional handle for later diversification.
This intermediate may be considered for medicinal chemistry libraries, pharmaceutical process development, agrochemical research, and custom synthesis programs. It is particularly relevant when a project needs a meta-substituted phenyl fragment bearing a boronic acid for coupling and a hydroxymethyl group for subsequent derivatization. Its usefulness should be confirmed through a small-scale reaction screen before committing to a larger campaign.
In discovery research, the compound can support rapid analog generation because the boronic acid and hydroxymethyl groups offer different reaction pathways. In process research, the main questions usually concern reproducible assay, impurity profile, isolation behavior, and scalability of the selected transformation. For commercial development, documentation and supply continuity become as important as the nominal chemical identity.
Commercial material may differ in assay, physical presentation, packaging, and documentation level. Some buyers require research-grade material for route exploration, while others need a controlled intermediate specification for repeated development batches. I recommend distinguishing between a catalog sample, a development-grade batch, and a material manufactured against an agreed specification.
Buyers should also ask whether the quoted material is supplied as the intended anhydrous form or whether water, residual solvent, or another solid-state variable may affect weighing and assay calculations. These details are not assumptions that can be resolved from the CAS number alone. A written specification and lot-specific analytical package are therefore important purchasing documents.
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For an initial technical review, I suggest checking identity, assay, water content, residual solvents, elemental impurities where relevant, and chromatographic impurity data. The appropriate limits depend on the compound’s use, the buyer’s internal quality system, and the stage of the project. A basic package should normally include a certificate of analysis and safety data sheet, with additional analytical information available when required.
| Review area | Why it matters |
|---|---|
| Identity confirmation | Helps verify that the shipped material matches CAS 87199-15-3. |
| Assay and purity | Supports accurate stoichiometry and comparability between lots. |
| Water and residual solvents | May influence weighing, reaction concentration, and process reproducibility. |
| Appearance and packaging | Helps assess shipment condition and handling suitability. |
| Documentation | Supports internal review, qualification, and safe laboratory use. |
Analytical methods should be selected according to the buyer’s quality requirements rather than copied automatically from another boronic acid. HPLC, NMR, mass spectrometry, water analysis, and other techniques may be relevant, but the final test plan should be agreed by the supplier and customer. I do not recommend treating an unverified purity percentage as a universal product specification.
As with other boronic acid intermediates, the material should be handled according to the current safety data sheet and the receiving organization’s chemical procedures. Personnel should use suitable personal protective equipment, avoid generating dust, and work with appropriate ventilation. The exact hazard classification, precautions, and disposal requirements should be taken from the supplier’s SDS for the supplied product and jurisdiction.
For storage, buyers commonly request a tightly closed container in a cool, dry, controlled area protected from incompatible conditions. Because moisture and repeated container opening can affect some chemical intermediates, I recommend minimizing unnecessary exposure and using packaging appropriate to the order size. Storage temperature, shelf-life, and retest information should be confirmed directly with the supplier rather than inferred from the chemical name.
Start by sharing the CAS number, intended application, required quantity, target assay, delivery location, and documentation expectations. If the material will enter a regulated development process, state whether you need traceability, change notification, impurity controls, or a defined retest period. This information allows the supplier to respond with a technically relevant quotation instead of a generic catalog price.
Price should be compared together with pack size, shipping conditions, lead time, payment terms, and the completeness of quality documents. A lower unit price may not represent better value if the material requires additional testing or creates delays during incoming inspection. Buyers should also ask whether repeat lots can be produced against the same specification and how deviations are communicated.
Maison Chemical supports B2B sourcing of 3-(Hydroxymethyl)phenylboronic acid CAS 87199-15-3 for research, development, and commercial evaluation. We can discuss product specifications, available quantities, packaging preferences, export documentation, and the analytical documents required for your review. Final availability, lead time, and pricing are confirmed according to the requested grade, quantity, destination, and current production schedule.
3-(Hydroxymethyl)phenylboronic acid CAS 87199-15-3 is a multifunctional aromatic intermediate with a boronic acid group for coupling chemistry and a hydroxymethyl group for further derivatization. Its commonly cited formula is C7H9BO3, and its approximate molecular weight is 151.96 g/mol. The compound can be relevant to medicinal chemistry, pharmaceutical intermediate development, and other programs requiring a functionalized phenyl building block.
The best purchasing decision depends on more than chemical identity: buyers should verify assay, identity data, water or residual solvent information, packaging, SDS, certificate of analysis, and supply continuity. Before placing an order, send Maison Chemical your target quantity, required specification, application stage, destination, and documentation requirements. We can then help determine the most suitable supply option and provide a quotation for your project.
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