If you are sourcing 1,4-Cyclohexanedione monoethylene acetal, CAS 4746-97-8, the most important buying checks are identity, assay, impurity profile, documentation, packaging, and supply continuity. I recommend confirming the product name, CAS number, molecular formula, molecular weight, appearance, analytical method, and batch-specific COA before placing an order. As a chemical supplier, Maison Chemical can support B2B buyers with specification review, quotation preparation, packaging discussion, and export coordination based on the required grade and quantity.
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This guide is intended for pharmaceutical intermediate manufacturers, research and development teams, process chemists, procurement departments, distributors, and international chemical buyers. It is especially useful when a buyer has found a CAS number but still needs to evaluate whether a supplier can provide suitable quality documentation and dependable delivery. The recommendations below are written for commercial sourcing rather than laboratory-scale identification alone.
Buyers should treat the published specification as a starting point, not a substitute for batch documentation. Requirements may differ between early-stage research, process development, pilot production, and commercial manufacturing. Before approval, I suggest aligning the supplier’s specification with your internal method, downstream process, regulatory file, and receiving inspection procedure.
1,4-Cyclohexanedione monoethylene acetal CAS 4746-97-8 is an organic building block in which one carbonyl functionality of 1,4-cyclohexanedione is protected as a cyclic ethylene acetal. It is also commonly associated with the chemical name 1,4-dioxaspiro[4.5]dec-8-one, although buyers should confirm the preferred nomenclature on the supplier’s technical documents. The commonly referenced molecular formula is C8H12O3, with a molecular weight of approximately 156.18 g/mol.
This structure can be useful when selective reaction control is needed during synthetic work. The acetal group may help protect one ketone while the remaining ketone is used for subsequent transformation, but actual suitability depends on the reaction conditions and the buyer’s process. I recommend evaluating the material through the complete intended synthesis rather than judging it only by name or assay.
The first verification point is whether the supplied material matches CAS 4746-97-8 and the agreed chemical name. A commercial specification may include molecular formula, molecular weight, appearance, assay, and identification by methods such as NMR, IR, or chromatography. The exact identification method should be agreed in advance when the material will enter a controlled pharmaceutical or regulated development process.
For routine purchasing, buyers often request an assay target such as a stated minimum percentage, together with limits for water, residual solvents, and related substances. I do not recommend assuming that a generic catalogue value meets your process requirement. The final acceptance criteria should be written into the quotation, specification sheet, or purchase agreement before order confirmation.
Assay alone may not describe all risks associated with this intermediate. A buyer should ask whether the COA reports related compounds, unreacted starting materials, over-reaction products, residual solvents, water content, and inorganic residues where relevant. The appropriate tests depend on the manufacturing route, intended use, and analytical capability available at the receiving site.
If the material is used in a multi-step synthesis, low-level impurities can sometimes affect crystallization, reaction selectivity, color, or downstream purification. For this reason, I suggest requesting representative chromatographic information or a typical impurity profile during technical evaluation, while distinguishing clearly between typical data and release specifications.
Confirm whether the product is supplied as a solid, powder, or another defined physical form, and request the expected appearance in the specification. Buyers should also review storage conditions, recommended container closure, shelf-life policy, and any available safety data. These details are important because transportation and storage conditions can influence material condition even when the original batch met its release criteria.
| Buyer Check | What to Confirm |
|---|---|
| Identity | CAS 4746-97-8, chemical name, formula, molecular weight, and identification method |
| Quality | Assay, related substances, water, residual solvents, and other agreed tests |
| Documentation | Batch number, test date, release date, specification version, and authorized approval |
| Supply | Available quantity, MOQ, production schedule, packaging, and delivery terms |
A certificate of analysis should be batch-specific and traceable to the material being shipped. I recommend checking the product name, CAS number, batch number, manufacturing or retest date, test methods, individual results, specification limits, and final release statement. The document should also identify the supplier or manufacturer and include an authorized quality approval where applicable.
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Do not accept a COA that provides only a broad statement such as “passes” without showing the relevant test results when your quality system requires numerical data. A useful COA allows the buyer to compare the result with the agreed limit and identify whether a value is a release specification or merely typical information. If a test is not included, ask the supplier to confirm whether it is available as an additional analysis.
Packaging should be selected according to order size, transport route, storage conditions, and handling requirements. Common commercial discussions may involve small sample quantities, research packs, or larger sealed containers, but the actual available pack size must be confirmed with the supplier. I advise buyers to specify the requested net weight, inner packaging, outer packaging, labeling format, and whether a particular container material is required by their quality system.
Minimum order quantity is not a universal property of the product. It can depend on available stock, production batch size, packaging configuration, export arrangements, and whether special testing is requested. For this reason, Maison Chemical reviews MOQ and pricing according to the buyer’s quantity, destination, grade, and documentation needs rather than presenting one assumption for every project.
Lead time should be divided into stock availability, quality release, packing, and transportation. A supplier may have material physically available but still require time for document confirmation, repacking, or export preparation. When planning a manufacturing campaign, I recommend requesting a written schedule with a target dispatch date and identifying which events could change that schedule.
A capable supplier should be able to discuss the product using its CAS number, chemical name, analytical profile, and intended application. The supplier should also understand the difference between a catalogue description, a typical specification, and a batch release document. If you require a special purity target or additional analysis, ask whether the request can be reviewed before quotation.
For international procurement, evaluate more than the unit price. Confirm the quotation currency, trade term, payment conditions, packaging details, shipping documents, and responsibility for export coordination. Maison Chemical supports buyers by collecting these requirements at the inquiry stage so that technical and commercial conditions can be reviewed together.
A single successful sample does not automatically demonstrate long-term supply capability. Ask how the supplier manages repeat orders, batch consistency, change communication, and forecast requirements. For a project with recurring demand, I recommend discussing estimated annual volume, preferred delivery frequency, safety stock expectations, and the process for handling future specification changes.
One frequent mistake is comparing suppliers only by assay percentage or price per kilogram. This can overlook impurity limits, analytical differences, packaging costs, documentation quality, and delivery risk. Another mistake is approving a sample without confirming that the commercial batch will be produced and released under the same agreed specification.
Buyers also sometimes request a quotation without stating the destination, quantity, required packaging, or document list. That makes it difficult to provide an accurate landed-cost and lead-time assessment. A complete inquiry should include the CAS number, target quantity, intended grade, delivery location, required documents, and any special quality or packaging requirements.
The best way to purchase 1,4-Cyclohexanedione monoethylene acetal CAS 4746-97-8 is to evaluate the complete supply package rather than the product name alone. Confirm identity and specifications first, then review the COA, packaging, MOQ, lead time, and supplier support against your project requirements. This approach helps reduce avoidable quality, documentation, and delivery risks.
To begin an inquiry with Maison Chemical, send your required quantity, destination, target specification, packaging preference, and document requirements. I can then help coordinate a product review, quotation, COA discussion, and supply plan suited to your research, development, or production stage.
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