2-Chlorophenylboronic acid, identified by CAS 3900-89-8, is an aromatic boronic acid used primarily as a building block in synthetic chemistry. Its key value comes from the boronic acid group, which can participate in palladium-catalyzed Suzuki–Miyaura coupling with suitable aryl or vinyl halides. The compound has the molecular formula C6H6BClO2 and a molecular weight of 156.37 g/mol. In this guide, I explain its chemical identity, common research and manufacturing uses, specification considerations, purchasing risks, and how I recommend evaluating a supplier.
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I have prepared this buying guide for pharmaceutical and agrochemical research teams, process development chemists, custom synthesis companies, chemical distributors, and procurement professionals sourcing specialty organic boronic acids. It is also useful for laboratories that need to compare pack sizes, purity grades, documentation, and supply continuity before placing an order. Because application requirements differ, I recommend treating the information below as a technical sourcing framework rather than as a substitute for project-specific validation.
2-Chlorophenylboronic acid is an organoboron compound containing a benzene ring substituted with chlorine and a boronic acid group in the adjacent, or ortho, position. The boronic acid functionality is the chemically reactive portion most commonly used for carbon–carbon bond formation. Its molecular formula is C6H6BClO2, and its relative molecular mass is 156.37 g/mol.
The compound is generally handled as a solid chemical intermediate, although the exact appearance, particle form, and stability can vary by manufacturing process and packaging. As with many boronic acids, moisture exposure, prolonged storage, and incompatible reaction conditions can affect material performance. I therefore recommend confirming the supplier’s current certificate of analysis, storage guidance, and retest or shelf-life policy before purchasing.
| Parameter | Information |
|---|---|
| Product name | 2-Chlorophenylboronic acid |
| CAS number | 3900-89-8 |
| Molecular formula | C6H6BClO2 |
| Molecular weight | 156.37 g/mol |
| Functional groups | Aryl chloride and boronic acid |
The aryl chloride and boronic acid groups give this molecule two different synthetic features. The boronic acid group is commonly used as a coupling partner, while the chlorine substituent may remain in the product as a functional handle or influence the electronic and steric properties of the aromatic ring. Whether the chlorine is retained or further transformed depends on the reaction sequence and catalyst system selected by the chemist.
Purity should be specified according to the intended application, not selected only by nominal grade. For many discovery and process-development projects, buyers may request an assay target of 98% or higher, but the appropriate acceptance limit must be confirmed against the reaction method and downstream requirements. I recommend requesting analytical data such as HPLC or GC where applicable, NMR identity confirmation, water content when moisture sensitivity matters, and residual solvent information when the material will enter a regulated or tightly controlled process.
A certificate of analysis should identify the batch number, test methods, measured results, specification limits, manufacturing date, and retest or expiry information where applicable. I do not recommend accepting a generic specification sheet as a replacement for batch-specific documentation. If the material is intended for scale-up, I also suggest checking whether the supplier can maintain consistent impurity profiles between development and production batches.
The most recognized use of 2-Chlorophenylboronic acid is as an arylboronic acid partner in Suzuki–Miyaura coupling. In a suitable catalytic system, the boronic acid group can couple with an aryl, heteroaryl, or vinyl halide to form a new carbon–carbon bond. This makes the compound relevant to the preparation of substituted biaryl structures and more complex aromatic intermediates.
Reaction success depends on more than the identity of the starting material. Catalyst choice, base, solvent, temperature, concentration, atmosphere, substrate compatibility, and work-up conditions can all influence conversion and selectivity. I advise users to validate the reaction on a small scale before assuming that a published or internally developed method will transfer directly to a new substrate.
Arylboronic acids are widely used in medicinal chemistry and process research because they enable modular assembly of aromatic structures. 2-Chlorophenylboronic acid can be selected when a chloro-substituted aromatic fragment is required in the target molecule or when the substitution pattern provides a useful starting point for subsequent transformations. Its suitability must be evaluated within the complete synthetic route, including impurity control and the fate of boron-containing residues.
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Research institutions and custom synthesis laboratories may use this material for route scouting, analogue preparation, reaction optimization, and intermediate production. Small quantities are often appropriate during screening, while larger quantities require greater attention to lot consistency, packaging, transport classification, and documentation. The purchasing specification should reflect the actual stage of the project rather than assume that a research-grade material automatically meets process-grade needs.
I recommend beginning with the intended transformation and the maximum acceptable impurity profile. Confirm whether the chlorine substituent must remain intact, whether the compound will be used in a metal-catalyzed coupling, and whether water or residual solvents could affect the reaction. This step helps prevent the common mistake of choosing a material solely by CAS number and price.
Define the required assay, identification tests, water limit, residual solvent expectations, appearance requirements, packaging format, and permitted impurities. A 98% assay target may be suitable for some exploratory applications, while regulated or process-sensitive work may require a tighter and more comprehensive specification. I recommend asking the supplier to confirm which analytical methods are routinely available before issuing a purchase order.
For early screening, a small package can reduce inventory exposure and avoid unnecessary material aging. For process development, buyers should evaluate whether the supplier can provide repeat batches with comparable analytical results. For commercial planning, I recommend discussing annual demand, forecast visibility, packaging sizes, and contingency supply rather than negotiating only the first shipment.
The price of 2-Chlorophenylboronic acid can vary with purity, order quantity, packaging, documentation requirements, production capacity, and shipping destination. A low quoted price may not represent the lowest total procurement cost if it excludes special testing, export documents, repacking, or additional quality review. I recommend comparing complete quotations on the basis of delivered cost and technical suitability.
Minimum order quantity is supplier-specific and may differ between available stock and custom production. Indicative lead times for specialty chemical orders may range from 1 to 4 weeks, but I treat this only as a planning estimate until stock status and production scheduling are confirmed. Buyers should request a written quotation stating the batch availability, estimated dispatch date, validity period, Incoterms, packaging, and payment conditions.
At Maison Chemical, I support B2B buyers by clarifying product requirements before quotation. Depending on the project, I can help review the requested purity, quantity, packaging, documentation, and delivery information for 2-Chlorophenylboronic acid CAS 3900-89-8. I encourage buyers to provide their target quantity, application stage, destination, and required documents so that the quotation can be prepared around the real procurement need.
2-Chlorophenylboronic acid CAS 3900-89-8 is a useful starting material when a chloro-substituted aryl fragment and boronic-acid coupling functionality are needed in an organic synthesis route. Its suitability depends on reaction compatibility, required purity, impurity control, and the intended scale. The most effective next step is to define your technical specification and request a batch-specific quotation rather than compare price alone.
Maison Chemical can assist with B2B sourcing discussions for 2-Chlorophenylboronic acid, including quantity planning, specification review, packaging requirements, and documentation expectations. Send us your target quantity, purity requirement, delivery destination, and project stage, and I will help determine the most appropriate supply option for evaluation.
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