2-Chlorophenylboronic acid, identified by CAS 3900-89-8, is an aryl boronic acid used primarily as a building block in organic synthesis. Its chlorine substituent and boronic acid group provide useful chemical handles for palladium-catalyzed Suzuki–Miyaura coupling and related research applications. I recommend evaluating identity, assay, water content, impurity profile, packaging, and shipping conditions before selecting a supplier.
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Maison Chemical supplies organic boronic acid products for research, process development, and industrial sourcing programs. Because product specifications can vary by grade and batch, I provide the confirmed certificate of analysis, available package sizes, lead time, and regulatory documentation during quotation rather than presenting unverified values as fixed specifications.
This guide is intended for procurement teams, medicinal chemistry groups, process chemists, contract research organizations, and manufacturers sourcing 2-chlorophenylboronic acid. It is also useful for buyers comparing catalog material with larger-volume custom or repeat supply. The focus is on practical selection rather than on a single laboratory procedure.
Buyers should use the information below as a purchasing and technical-screening framework. A project-specific risk assessment remains necessary because the required purity, analytical package, packaging format, and shipping controls depend on the intended reaction and scale.
2-Chlorophenylboronic acid is an ortho-chloro-substituted aryl boronic acid. The boronic acid group can participate in carbon–carbon bond-forming chemistry, while the chlorine atom may remain in the product as a functional substituent or serve as a separate point for downstream transformation. This combination makes the compound relevant to discovery chemistry and intermediate development.
| Item | Information | Purchasing relevance |
|---|---|---|
| Product name | 2-Chlorophenylboronic acid | Confirm the ortho-substituted isomer |
| CAS number | 3900-89-8 | Use for identity matching across supplier documents |
| Molecular formula | C6H6BClO2 | Check against the supplier specification and label |
| Approximate molecular weight | 156.38 g/mol | Useful for molar calculations and formulation planning |
| Functional groups | Aryl chloride and boronic acid | Relevant to coupling design and downstream chemistry |
The molecular formula and approximate molecular weight above are consistent with publicly available chemical reference information. PubChem should be checked as an identity reference, while the supplier’s certificate of analysis should be treated as the controlling document for a particular batch. See the PubChem search record for an independent reference point.
The most common reason to source an aryl boronic acid is its use as a coupling partner with an aryl or heteroaryl halide. In a Suzuki–Miyaura reaction, the boronic acid fragment can be transferred to a palladium-containing catalytic system under suitable base, solvent, temperature, and atmosphere conditions. Actual conversion and selectivity depend on the reaction design, so no universal yield should be assumed from the chemical name alone.
2-Chlorophenylboronic acid can be selected when the target molecule requires an ortho-chlorophenyl fragment. The chlorine may be retained for electronic or steric effects, or it may offer an additional functionalization opportunity in a later step. Chemists should confirm that the relative position of the chlorine and boronic acid groups matches the target structure before ordering.
In medicinal chemistry, this compound may be used to prepare substituted biaryl or heteroaryl structures during analogue synthesis. In process and materials research, it may serve as a defined aromatic intermediate for route scouting or small-scale development. Its suitability should be verified through a reaction-specific evaluation because steric effects from the ortho chlorine can influence coupling behavior.
For early-stage work, buyers may prioritize small package availability, rapid documentation, and dependable analytical identity. For process development, lot consistency, impurity control, scalable packaging, and repeat supply are usually more important than the lowest initial price. I recommend discussing both the immediate quantity and the expected annual or project demand with the supplier.
Commercially available material may differ by purity target, analytical documentation, package size, and intended use. A research-grade product may be suitable for screening, while a process-development project may require tighter controls for assay, related substances, residual solvents, water, and trace metals. These categories should be confirmed from the actual specification rather than inferred from a marketing label.
The free boronic acid should not automatically be treated as interchangeable with a boronate ester. Molecular weight, solubility, hydrolytic behavior, weighing calculations, and reaction performance may differ between forms. Before approving an alternative, I recommend confirming the chemical form, purity basis, assay calculation, and suitability in the buyer’s validated or intended process.
A reliable inquiry should request more than a product name and CAS number. At minimum, I suggest asking for assay or purity, water content where relevant, related substances, residual solvents, heavy metals or elemental impurities if applicable, appearance, and a current certificate of analysis. The buyer should also confirm whether reported purity is area percent, weight percent, or another analytical basis.
| Specification area | Questions for the supplier |
|---|---|
| Identity | Does the documentation confirm CAS 3900-89-8, formula, and structure? |
| Assay | What method is used, and what is the reporting basis? |
| Related substances | Are positional isomers, dehalogenated compounds, or other organic impurities controlled? |
| Water and solvents | Are Karl Fischer water results and residual-solvent data available when required? |
| Packaging | Can the material be supplied in containers such as 25 g, 100 g, 500 g, or a project-specific size? |
| Documentation | Are SDS, COA, lot information, and transport documents available before shipment? |
Package sizes such as 25 g, 100 g, and 500 g are inquiry examples, not a promise of current stock. The appropriate quantity depends on laboratory consumption, process demand, stability, and the buyer’s inventory policy. I can confirm available pack sizes and documentation for the required destination during the quotation stage.
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Start by matching the supplier’s name, CAS number, molecular formula, and structural representation. The “2-chloro” designation indicates the relative position of chlorine on the phenyl ring, and positional isomers should not be accepted without technical approval. If the compound will enter a regulated or tightly controlled process, request an identity package that supports the intended use.
Set the purity and impurity requirements according to the reaction sensitivity and downstream risk. A discovery screen may need a different specification from a process intermediate, especially where residual metals, water, or trace organic impurities affect reproducibility. It is more efficient to define acceptance criteria before comparing quotations.
Estimate demand in grams or kilograms, then separate trial quantity from forecast quantity. A supplier may offer different pricing, packaging, or lead-time options at each volume level, but the commercial proposal should be based on confirmed availability. Buyers should also ask whether repeat lots can be planned against a rolling forecast.
Check the SDS, COA format, lot traceability, packaging description, storage guidance, export documents, and destination-country requirements. For international shipments, the buyer should confirm importer responsibilities, customs classification with the relevant broker, and any special transport restrictions. Maison Chemical can coordinate the technical and commercial information needed for a sourcing review.
The price of 2-chlorophenylboronic acid is normally influenced by quantity, purity target, packaging, analytical requirements, production status, and shipping destination. A small laboratory pack and a larger project quantity should not be compared only by unit price because documentation and logistics may differ. I recommend requesting a tiered quotation that separates product, packaging, testing, and freight where practical.
Minimum order quantity is supplier- and project-dependent, so it should be confirmed in writing. Lead time may range from available stock to a production schedule, but an exact number of days should only be quoted after checking inventory, batch release, packaging, and export requirements. For planning, buyers should request both the earliest dispatch date and the expected arrival window.
Cost control should include the risk of failed reactions, delayed release, and unsuitable packaging. A slightly higher specification may be commercially preferable if it reduces requalification or repeat testing, but that decision should be based on the buyer’s process evidence. The best quotation is therefore the one that meets the technical requirement with a clear and realistic supply plan.
Another frequent mistake is treating a catalog listing as a complete technical offer. A listing may not show current lot data, packaging conditions, or destination-specific documentation. I recommend approving the batch only after reviewing the actual COA and the documents required by your quality and procurement teams.
Maison Chemical can support inquiries for 2-chlorophenylboronic acid by coordinating product identity confirmation, specification review, packaging discussion, quotation, and delivery planning. My approach is to clarify the intended application, quantity range, purity expectations, and destination before recommending a supply option. This helps avoid a mismatch between a nominally correct product and the buyer’s actual process requirements.
For repeat or development programs, I can also help organize a supply discussion around forecast volumes, batch documentation, sampling requirements, and replenishment timing. Any available stock position, MOQ, lead time, and quality document should be confirmed at the time of inquiry. This is especially important when the material is needed across multiple development stages.
2-Chlorophenylboronic acid CAS 3900-89-8 is an aryl boronic acid building block with a molecular formula of C6H6BClO2 and an approximate molecular weight of 156.38 g/mol. Its principal value is the combination of a coupling-capable boronic acid group and an ortho chlorine substituent for constructing or retaining functionalized aromatic structures. The correct purchasing decision depends on confirmed identity, fit-for-purpose quality, documentation, quantity, and supply reliability.
As a next step, send Maison Chemical your required quantity, target purity, intended application, preferred package size, destination country, and documentation requirements. I can then help confirm the available specification, COA and SDS status, MOQ, quotation basis, and estimated lead time. This information provides a practical basis for approving 2-chlorophenylboronic acid for research or process-development procurement.
Request a technical and commercial quotation from Maison Chemical for 2-Chlorophenylboronic acid CAS 3900-89-8.
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