4-Isopropylbenzeneboronic acid, also known as 4-isopropylphenylboronic acid, is an aryl boronic acid used primarily as a building block in organic synthesis. Its listed Chemical Abstracts Service (CAS) number is 16152-51-5, and its molecular formula is generally represented as C9H13BO2, with a calculated molecular weight of approximately 164.01 g/mol. I recommend treating it as a research and synthesis intermediate rather than as a finished active ingredient or commodity chemical. For purchasing, the most important checks are identity, assay, water content, residual solvents, packaging, documentation, and supply scale.
This guide is intended for pharmaceutical and agrochemical research teams, medicinal chemistry laboratories, specialty chemical distributors, process-development groups, and procurement professionals sourcing 4-isopropylbenzeneboronic acid. It is also relevant to buyers comparing small research quantities with larger custom or repeat-order requirements. I focus on practical supplier evaluation rather than presenting unverified product claims.
The compound may be suitable for organizations developing substituted biaryl structures, screening synthetic routes, or preparing intermediates for further transformation. Because commercial specifications can differ by manufacturer and batch, buyers should confirm the current specification sheet and certificate of analysis before placing an order. The information below is a sourcing framework and should not replace laboratory risk assessment or process validation.
4-Isopropylbenzeneboronic acid contains an aryl boronic acid group and an isopropyl substituent in the para position of the benzene ring. The boronic acid functionality is chemically valuable because it can participate in transition-metal-catalyzed carbon–carbon bond-forming reactions, especially Suzuki–Miyaura coupling when paired with a suitable aryl or vinyl electrophile. The isopropyl group can provide a hydrophobic substituent that may influence steric properties, lipophilicity, and the behavior of the final molecule.
Its approximate molecular weight is 164.01 g/mol, and the boron content calculated from the formula is approximately 6.59% by mass. The material should not be confused with an isopropyl-substituted boronate ester, a potassium organotrifluoroborate, or another protected boron reagent. These forms can have different molecular weights, handling requirements, reactivity profiles, and analytical methods.
For identity confirmation, I recommend using at least two complementary techniques where practical, such as proton nuclear magnetic resonance (1H NMR), carbon nuclear magnetic resonance (13C NMR), liquid chromatography or gas chromatography where suitable, and high-resolution or routine mass spectrometry. PubChem provides a useful public reference point for chemical identity and structure checking, while the supplier’s batch-specific certificate remains the controlling document for a purchased lot. National Center for Biotechnology Information PubChem should be consulted alongside supplier documentation.
The most direct purchasing option is the neat compound supplied as a solid. Buyers should confirm whether the material is offered as a crystalline powder, amorphous solid, or another physical form because appearance alone does not establish identity or purity. A neat product is often preferred when the customer needs to control reaction concentration, solvent selection, and charge quantity independently.
Research quantities may be offered in packages such as 1 g, 5 g, or 25 g, subject to supplier availability. These quantities are useful for route scouting, parallel medicinal chemistry, and early-stage reaction screening. The buyer should verify whether the stated amount is net content, whether the package is moisture-protected, and whether the same specification applies across all pack sizes.
For process development, a buyer may require a larger campaign quantity, repeat delivery, or a manufacturing route review. In that situation, I recommend requesting a written discussion of scale, batch size, production lead time, analytical release criteria, and change-control practice. A supplier should not be judged only by the availability of a small catalog pack if the intended project requires reliable multi-batch supply.
| Specification area | What to confirm | Why it matters |
|---|---|---|
| Identity | CAS 16152-51-5, chemical name, molecular formula, and structural representation | Prevents confusion with related boronic acids and boronate esters |
| Molecular weight | Approximately 164.01 g/mol for the stated formula | Supports weighing calculations and reaction stoichiometry |
| Assay or purity | Analytical method, reporting basis, and acceptance limit | Helps estimate effective reagent loading |
| Water content | Result in %, preferably with the test method identified | Water can affect moisture-sensitive reactions and material consistency |
| Residual solvents | Solvent names, limits in ppm, and analytical method | Important for process safety, reproducibility, and downstream purification |
| Physical description | Color, form, and storage conditions | Provides a basic incoming-inspection reference |
| Packaging | Container type, liner, closure, net weight, and labeling | Supports transport and moisture-control planning |
Do not assume that a purity value such as 98% or 99% is available unless it appears in the current product specification or certificate of analysis. I also recommend asking whether the reported assay is area percent, weight percent, or another basis. For regulated or tightly controlled development work, the buyer may additionally request elemental analysis, heavy-metal information, residual palladium, and a defined impurity profile, depending on the reaction route and intended use.
The principal application category for aryl boronic acids is cross-coupling with suitable aryl, heteroaryl, or vinyl electrophiles. In a typical development program, the boronic acid is evaluated as one component of a reaction system that also includes a catalyst, base, solvent, temperature profile, and work-up procedure. The actual conversion and selectivity depend on the reaction design, so I would not promise a universal yield or fixed operating condition for this substrate.
The para-isopropyl substitution can be useful when a project needs a nonpolar aryl fragment rather than an unsubstituted phenyl group. It may also help medicinal chemists compare steric and hydrophobic effects across a small compound series. These are design considerations, not guarantees of biological performance, and the final molecule must be evaluated independently.
Discovery teams may use 4-isopropylbenzeneboronic acid to introduce a substituted phenyl unit into candidate molecules. The material can be relevant to parallel synthesis, analog generation, and structure–activity relationship studies where a boronic acid building block is required. For these uses, dependable identity, consistent purity, and small-pack availability may be more important than the lowest nominal price.
Process chemists generally need more than a catalog listing. They may require batch-to-batch consistency, impurity trend information, reaction-performance data generated under an agreed protocol, and an achievable delivery schedule. I recommend separating early route-screening requirements from later commercial-scale requirements because the acceptance criteria, quantity, and risk profile may change significantly.
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Start by stating whether the material is intended for analytical research, reaction screening, medicinal chemistry, process development, or manufacturing support. This determines the appropriate package size, documentation level, analytical testing, and delivery expectations. A 1 g screening order and a repeated kilogram-scale requirement should not be evaluated using the same sourcing criteria.
Ask the supplier to confirm the exact name, CAS number, formula, molecular weight, and whether the material is the free boronic acid or a protected derivative. Where the specification is important, request an analytical data package that may include NMR, chromatographic data, Karl Fischer water testing, and mass spectrometry. I recommend resolving any discrepancy between the product page, quotation, label, and certificate before shipment.
At minimum, request a current specification sheet and a batch-specific certificate of analysis. Depending on the project, useful documents may include a safety data sheet, handling guidance, transport classification, residual-solvent statement, and change-notification policy. A supplier’s ability to provide clear documents is a practical indicator of whether the material can be integrated into a controlled procurement process.
Unit price is only one part of the purchase decision. Include packaging, hazardous-goods handling where applicable, freight, import documentation, analytical testing, minimum order quantity, and the cost of delays or rejected material. I recommend requesting a quotation for at least two quantity levels, such as 5 g and 25 g, to understand the price curve without assuming that a larger order is automatically more economical.
Ask whether the quoted lead time is based on inventory, scheduled production, or a new manufacturing campaign. Confirm the quotation validity period, shelf-life information if available, storage conditions, and whether future batches will be made under the same stated process. For a route-development project, an apparently short first delivery may have limited value if repeat supply cannot be planned.
Publicly available prices and minimum order quantities can vary by region, pack size, purity grade, stock status, and shipping requirements. I therefore recommend treating online prices as indicative rather than final. A written quotation should identify the exact product, net quantity, packaging, Incoterms where relevant, documentation included, payment terms, and estimated dispatch date.
Lead time should be divided into material availability, quality release, packaging, and transportation. For example, a supplier may have material physically available but still require several business days for testing and export preparation. Buyers should also ask whether the quoted date is an estimate or a committed dispatch date, and what notification process applies if the schedule changes.
For repeat programs, a forecast can help both parties plan production and inventory. However, I recommend avoiding unnecessary commitments until the customer has confirmed reaction suitability and incoming quality. A staged purchasing plan—small quantity for screening, intermediate quantity for route confirmation, and larger quantity after process approval—can reduce technical and commercial risk.
For chemical handling and hazard communication, I recommend consulting the supplier’s current safety data sheet and the applicable national requirements rather than relying on a generic internet description. The United Nations Globally Harmonized System of Classification and Labelling of Chemicals provides an authoritative framework for hazard communication, although the classification of a specific supplied product must be confirmed from its current SDS. UNECE GHS information is a suitable reference for the general framework.
At Maison Chemical, I can help buyers organize the technical and commercial information needed to evaluate 4-isopropylbenzeneboronic acid. Our support can include specification review, quantity-based quotation, document coordination, packaging discussion, and communication about sample or repeat-order requirements. The exact availability, purity grade, MOQ, and lead time should be confirmed in the quotation for the requested quantity and destination.
For a more efficient inquiry, please provide the required quantity, target purity, intended application, delivery country, preferred packaging, and documentation requirements. If you are developing a coupling route, it is also useful to indicate whether you need only a catalog-grade building block or a more detailed quality package. I can then help define a practical request without overstating specifications that have not yet been confirmed.
4-Isopropylbenzeneboronic acid CAS 16152-51-5 can be a useful substituted aryl building block for research and process-development chemistry, but the right supplier choice depends on more than the chemical name and nominal price. I recommend confirming the exact material form, analytical specification, certificate of analysis, packaging, delivery schedule, and future supply plan before approval. These checks are particularly important when a project is moving from gram-scale screening toward repeated or larger-volume procurement.
To begin, prepare a short purchasing brief that lists the target quantity, acceptable purity, required documents, delivery location, and intended use. Send that information to Maison Chemical for a product and supply review, then compare the resulting quotation with your internal technical and quality requirements. This approach helps convert a basic CAS-number search into a controlled B2B sourcing decision.
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