1,4-Cyclohexanedione, identified by CAS 637-88-7, is a cyclic diketone with the molecular formula C6H8O2 and a molecular weight of 112.13 g/mol. Its ring contains two ketone groups positioned opposite each other at the 1,4-positions, giving the molecule useful reactivity for organic synthesis. I regard it primarily as a specialty chemical intermediate for pharmaceutical, fine chemical, and research applications rather than as a finished active ingredient. For B2B purchasing, the most important checks are identity, assay, impurity profile, packaging, documentation, and supply consistency.
1,4-Cyclohexanedione is a six-carbon cyclic compound containing two carbonyl functional groups. The carbonyl groups can participate in common organic reactions, including condensation, reduction, derivatization, and other transformations selected by the process chemist. This functionality makes the material valuable when a synthesis requires a symmetrical diketone building block.
| Property | Information |
|---|---|
| Product name | 1,4-Cyclohexanedione |
| CAS number | 637-88-7 |
| Molecular formula | C6H8O2 |
| Molecular weight | 112.13 g/mol |
| Functional groups | Two ketone carbonyl groups |
| Physical form | Typically supplied as a solid; confirm appearance and form against the current specification |
The molecular structure explains both its usefulness and its handling requirements. Because it contains two ketone groups, it may be sensitive to reaction conditions, moisture exposure, contamination, or prolonged storage conditions depending on the formulation and packaging. I recommend that buyers use the supplier’s current SDS and certificate of analysis rather than relying only on a general database description.
One major role of 1,4-cyclohexanedione is as a starting material or intermediate in multi-step organic synthesis. Process and medicinal chemists may use its two carbonyl groups to introduce ring functionality, build condensed structures, or prepare substituted cyclohexane derivatives. The exact suitability depends on the intended reaction route, catalyst system, solvent, purification method, and impurity tolerance.
I recommend treating it as a route-specific intermediate rather than assuming that one grade will fit every pharmaceutical project. Early-stage research may prioritize availability and analytical characterization, while process development generally requires tighter control of assay, related substances, residual solvents, water, and batch-to-batch consistency. Final acceptance should always be based on the buyer’s approved internal specification.
Laboratories may also purchase 1,4-cyclohexanedione for reaction development, synthetic screening, method studies, and preparation of downstream reference compounds. Its defined molecular structure allows researchers to compare reaction behavior across a range of catalysts and conditions. For these uses, dependable identity confirmation and suitable packaging are often more important than simply selecting the lowest nominal price.
A responsible sourcing review starts with a clear specification. At minimum, I suggest requesting the product name, CAS number, molecular formula, molecular weight, appearance, assay method, assay result or specification limit, and impurity controls. Buyers should also determine whether the material is intended for laboratory research, commercial synthesis, or a regulated pharmaceutical development program.
I avoid presenting a single universal purity value because commercial specifications can vary by grade, production route, and customer application. A buyer should compare the actual current specification with the process requirement, not just compare a product title or catalog description. If a supplier cannot clearly explain its test items, release criteria, or document control, the sourcing risk is higher.
1,4-Cyclohexanedione should be handled as an industrial or laboratory chemical under a documented risk assessment. Personnel should consult the current SDS for hazard classification, required personal protective equipment, first-aid measures, spill response, and storage guidance. I recommend minimizing dust generation, preventing unnecessary skin or eye contact, and using suitable ventilation during weighing and charging.
Storage conditions should be selected according to the supplier’s SDS and stability information. In general, the material should remain in a tightly closed, clearly labeled container and be protected from incompatible materials, contamination, excessive heat, and uncontrolled moisture exposure. Buyers should also establish a stock rotation policy and inspect packaging before use, especially after international transportation.
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Before scaling a reaction, I suggest confirming solubility, addition rate, mixing behavior, and compatibility with the selected solvent and process equipment. These practical factors can affect yield, filtration, and worker exposure even when the chemical identity is correct. Small-scale laboratory verification is a prudent step before committing to a larger purchase.
When I evaluate a supplier, I first compare the supplier’s product specification with the buyer’s actual synthesis and quality requirements. The supplier should be able to identify the material consistently, provide batch-specific documentation where applicable, and explain how packaging and storage are managed. For pharmaceutical-intermediate projects, I also recommend discussing change notification expectations before the first commercial order.
Do not assume that a low price represents the lowest total cost. A material with unsuitable impurity levels may create additional purification, investigation, or reprocessing work. I encourage buyers to consider the cost of qualification, testing, rejected material, lead-time disruption, and technical communication alongside the quoted price.
Request a clear quotation that states grade, pack size, quantity, Incoterm, delivery destination, estimated lead time, payment terms, and quotation validity. A supplier may offer different packaging options for sample quantities, development orders, and regular production supply. For planning purposes, buyers should confirm whether the material is available from stock or produced after order placement rather than relying on a generic lead-time estimate.
MOQ is also application-dependent. A research group may need only a small evaluation quantity, while a manufacturing customer may need a repeatable supply plan with scheduled releases. I recommend starting with a technically representative sample or pilot quantity when the route is not yet qualified, followed by a commercial supply review after the material passes internal testing.
At Maison Chemical, we supply 1,4-Cyclohexanedione CAS 637-88-7 for customers evaluating pharmaceutical intermediates, fine chemicals, and synthetic research materials. We focus on practical B2B communication: confirming the requested grade, discussing quantity and packaging, aligning documentation needs, and clarifying delivery expectations before an order is finalized. Our role is to help buyers make a specification-based purchasing decision rather than encourage an unsuitable standard product.
We can support an inquiry by reviewing the intended application, target quantity, required documents, destination country, and preferred delivery schedule. If your organization has an internal specification, please share the key acceptance parameters so we can assess product fit more accurately. For a new project, I recommend requesting the current specification and COA format first, then confirming sample or production-order requirements with our sales team.
1,4-Cyclohexanedione CAS 637-88-7 is a structurally defined cyclic diketone used mainly as an intermediate for organic synthesis and related research. It may be a suitable choice when your route requires a symmetrical six-carbon diketone with two reactive carbonyl groups, but the correct grade must be confirmed against your process and quality requirements. I recommend beginning with the intended reaction, required impurity limits, quantity, and documentation package rather than selecting solely by CAS number.
For the next step, prepare your target quantity, application, specification, packaging preference, destination, and required delivery window. Contact Maison Chemical with these details to request current product information and a B2B quotation for 1,4-Cyclohexanedione. We can then help you evaluate technical fit and organize a supply approach appropriate for your development or production plan.
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