4-Aminophenylboronic acid picol ester CAS 214360-73-3 is a specialized aryl boronic ester used primarily as a synthetic building block in research and process-development chemistry. It combines a para-amino-substituted phenyl group with a boron-containing ester functionality, making it relevant to cross-coupling and other transformations involving aryl boron reagents. I recommend that buyers confirm the exact ester nomenclature, structure, purity, and analytical documentation before placing an order, especially because “picol ester” can be confused with similarly named boronic esters such as pinacol esters.
4-Aminophenylboronic acid picol ester is an organoboron compound identified for purchasing and specification purposes by CAS No. 214360-73-3. Its structure contains an aniline-type amino group positioned at the para location of an aromatic ring and a boronic ester group attached to that ring. The boronic ester protects the boronic acid functionality while allowing the compound to serve as a practical intermediate in synthetic chemistry.
In my experience, the CAS number should be treated as the starting point for identification, not as a substitute for a complete quality review. Buyers should compare the supplier’s product name, structural representation, molecular formula, molecular weight, assay method, and lot-specific certificate of analysis. If the commercial name differs from the name shown on the SDS or CoA, I recommend asking the supplier to explain the relationship before technical approval.
The main value of this compound is its ability to introduce a 4-aminophenyl fragment into a larger molecule through boron-mediated synthetic methods. Aryl boronic esters are commonly selected as partners in palladium-catalyzed Suzuki–Miyaura coupling, although the appropriate catalyst, base, solvent, temperature, and work-up depend on the reaction system. The amino group also provides a useful functional handle for subsequent derivatization, protection, salt formation, or incorporation into more complex research compounds.
Because the molecule contains both a reactive amino group and a boronic ester, chemists must consider functional-group compatibility during route design. The amino group may require protection in some reaction sequences, while the boronic ester can be affected by water, pH, heat, or extended storage depending on the surrounding conditions. I therefore recommend evaluating this material as a route-specific intermediate rather than assuming that one set of conditions will apply to every application.
This compound can be considered for the preparation of substituted biaryl and heteroaryl structures during early-stage medicinal chemistry. The para-amino group may be retained as part of a target molecule or transformed into another functional group through established synthetic operations. Its suitability should be confirmed through small-scale experiments because reaction performance depends on the coupling partner and the complete molecular design.
Research teams developing agrochemical candidates, advanced intermediates, or specialty organic molecules may evaluate this material when a 4-aminophenyl unit is required. The compound is most relevant where a controlled carbon–carbon bond-forming step is part of the route. It is not, by itself, an indication of regulatory approval, biological activity, or suitability for direct use in a finished product.
Process chemists may use the compound during route scouting, impurity investigations, or scale-up studies. At larger scale, they should review not only assay but also residual solvents, water content, particle characteristics, filtration behavior, and batch-to-batch consistency. These factors can affect isolation and handling even when the reported chemical purity appears acceptable.
The most important distinction is the identity of the ester group. “Picol ester” should be confirmed against the chemical structure and CAS record because it may be confused in purchasing systems with “pinacol ester,” a different and widely used boronic ester nomenclature. I do not recommend approving a material based only on a shortened marketplace title.
Buyers may also encounter different supply grades, including research grade, higher-purity development material, and custom-prepared batches. These labels are not interchangeable quality standards, so I recommend requesting the actual assay method and specification sheet. When a project moves from discovery to process development, the required controls may change substantially.
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A purchasing review should include the compound identity, CAS number, appearance, assay or purity, water content, residual solvents, and relevant chromatographic data. The CoA should identify the lot number, test date, analytical method, and acceptance criteria. Where the material will enter a regulated or quality-sensitive workflow, buyers may also request impurity profiles, elemental analysis, and change-control information.
| Review Item | Why It Matters |
|---|---|
| CAS No. 214360-73-3 | Supports identity matching across quotation, SDS, CoA, and purchasing records. |
| Structural name and drawing | Helps distinguish “picol ester” from similarly named boronic ester products. |
| Assay and analytical method | Shows how the stated purity was measured and defined. |
| Water and residual solvent data | Provides practical information for moisture-sensitive or scale-up chemistry. |
| Packaging and storage statement | Supports appropriate handling after receipt and during laboratory use. |
I suggest beginning with the intended reaction and the minimum acceptable analytical profile. For an exploratory project, a buyer may prioritize availability, documentation, and a small evaluation quantity; for process development, the focus should shift toward reproducibility, impurity control, packaging, and supply continuity. The final specification should be agreed before the quotation is compared on price alone.
When comparing commercial offers, I recommend requesting pricing at several levels, such as 0.1 g, 1 g, and 10 g, when those quantities are relevant to the project. These quantity points can reveal whether the supplier supports both laboratory evaluation and larger development needs. Actual MOQ and lead time should be confirmed for each batch because stock status, synthesis scheduling, and testing requirements may change.
Buyers should also distinguish between in-stock material and made-to-order material. In-stock products may be suitable for rapid screening, while custom production may provide more control over specification and quantity but require additional planning. I recommend asking for the quotation validity, shipping conditions, packaging format, and whether the quoted lead time includes quality release.
At Maison Chemical, I approach this product as a B2B chemical sourcing project rather than a simple catalog transaction. I can help buyers align the requested product name and CAS number with the intended structure, quantity, purity target, and application stage. Where the nomenclature requires clarification, I recommend resolving that point before commercial confirmation.
For an inquiry, I suggest providing the required quantity, target purity, destination country, preferred packaging, and whether a CoA or SDS is needed before shipment. I can then review the appropriate supply route and clarify whether the material is available from stock or requires production planning. For repeat projects, buyers should also discuss batch consistency, documentation expectations, and forecast requirements.
4-Aminophenylboronic acid picol ester CAS 214360-73-3 is a specialized aryl boronic ester intended mainly for research synthesis and intermediate development. Its principal value comes from the combination of a para-amino aromatic group and a boron-containing functionality that can support carbon–carbon bond formation. The most important purchasing issue is precise identity confirmation, particularly when “picol ester” may be confused with another boronic ester name.
For a reliable B2B purchase, I recommend evaluating structure, CAS number, analytical data, quantity, packaging, lead time, and documentation together. Maison Chemical can support the inquiry by clarifying the requested specification and preparing a supply discussion suited to laboratory, development, or custom-order needs. Send the required quantity and target specification to begin a focused quotation review.
The direct answer is that 4-Aminophenylboronic acid picol ester CAS 214360-73-3 is an organoboron synthetic building block with potential value in medicinal chemistry, specialty intermediate development, and process research. It should be selected according to the complete structure and analytical specification, not the product title alone. Before purchasing, I recommend confirming the ester nomenclature, reviewing the lot documentation, and matching the quantity to the project stage.
Your next step is to prepare the CAS number, desired quantity, purity requirement, destination, and documentation needs for supplier review. Maison Chemical can then help assess the appropriate commercial option and clarify availability, MOQ, packaging, and lead-time expectations without making assumptions about your application. This approach reduces identity risk and creates a clearer basis for technical and purchasing approval.
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