2-(thiophen-2-yl)phenol CAS 106584-13-8 is an aromatic sulfur-containing compound that combines a phenol ring with a thiophene ring. I describe it as a research and synthesis intermediate rather than as a finished pharmaceutical ingredient, because its practical value depends on the specific reaction route and downstream product. The compound is identified by CAS Registry Number 106584-13-8, has the molecular formula C10H8OS, and a calculated molecular weight of approximately 176.24 g/mol.
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At Maison Chemical, I support buyers who need this compound for medicinal chemistry, advanced organic synthesis, materials research, or screening programs. The most important purchasing questions are usually identity, assay, impurity profile, packaging, documentation, and supply continuity. Because specifications can vary by application, I recommend confirming the required grade and analytical package before placing a commercial order.
2-(thiophen-2-yl)phenol is a biaryl-type molecule containing two chemically different aromatic systems: a phenol ring and a thiophene ring. The hydroxyl group on the phenol portion can participate in hydrogen bonding and may be used as a functional handle in further chemical transformations. The sulfur-containing thiophene portion contributes a heteroaromatic structure that is commonly encountered in medicinal chemistry and functional organic materials.
The name also communicates the substitution pattern. “Thiophen-2-yl” indicates that the thiophene fragment is connected through its 2-position, while the “phenol” portion identifies an aromatic hydroxyl group. For procurement and laboratory documentation, I recommend using the full chemical name together with CAS 106584-13-8 rather than relying on informal short names.
The compound’s molecular formula is C10H8OS, and its approximate molecular weight is 176.24 g/mol. In practical terms, 1.00 mol of the substance corresponds to approximately 176.24 g, which is useful when converting between molar quantities and batch weights. A 1.00 g quantity would theoretically represent about 5.67 mmol before accounting for assay or purity.
The phenolic hydroxyl group is the most obvious reactive feature for many synthesis plans. Depending on the selected reaction conditions, it may be involved in ether formation, esterification, protection and deprotection strategies, or other transformations used to build more complex molecules. The thiophene ring can also serve as a structural component in molecules being evaluated for electronic, optical, or biological properties.
I advise buyers to treat 2-(thiophen-2-yl)phenol as a laboratory chemical and to follow the current supplier safety data sheet, applicable workplace rules, and the risk assessment for the intended process. Appearance, melting behavior, solubility, and stability should be confirmed from the batch-specific documentation rather than assumed from the chemical name alone. Packaging should remain closed and appropriately labeled during storage and handling.
Solubility is especially important during route development. Aromatic compounds with phenolic and heteroaromatic structures may show different behavior in water, alcohols, ethers, chlorinated solvents, or polar aprotic solvents, but the actual result depends on solvent quality, temperature, concentration, and sample purity. I recommend a small-scale compatibility check before designing a larger reaction or crystallization process.
One potential use is as a building block or intermediate in medicinal chemistry programs. Researchers may incorporate the phenol-thiophene arrangement into a larger screening library and then modify the hydroxyl group, aromatic substitution pattern, or adjacent functional groups. I would not describe the compound itself as an approved active pharmaceutical ingredient unless the buyer has separate regulatory evidence for a specific product.
The compound can be considered when a synthesis requires a linked phenolic and thiophenyl architecture. Its structure may be useful for preparing protected derivatives, coupling partners, or more highly functionalized aromatic intermediates. The suitability of the material should be judged by the intended reaction, catalyst system, solvent, and impurity tolerance.
Thiophene-containing aromatic structures are also investigated in organic materials and functional molecule research. In these projects, the compound may be used as an intermediate for molecules designed for particular optical, electronic, or supramolecular studies. Such applications are research-dependent, so I recommend evaluating the final molecular design rather than assuming that every thiophene-containing intermediate will provide the same performance.
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For this type of specialty chemical, “material option” usually refers to the grade, assay target, package size, and documentation level rather than to a different basic chemical identity. A research buyer may need a small quantity for feasibility experiments, while a process-development team may require a more tightly controlled impurity profile and repeatable batch-to-batch supply. I help align the specification with the actual stage of the project.
| Buyer requirement | What I recommend confirming |
|---|---|
| Identity confirmation | CAS number, chemical name, molecular formula, and batch analytical data |
| Purity requirement | Assay method, reporting basis, related substances, and required acceptance limits |
| Research quantity | Available package size, sample policy, and shipping conditions |
| Scale-up quantity | Manufacturing route, production capacity, lead time, and batch consistency |
I avoid presenting one universal purity value when the buyer’s application has not been defined. A specification suitable for early discovery work may not be sufficient for a regulated development program or a sensitive multi-step synthesis. The correct approach is to match the analytical requirements to the reaction and downstream quality expectations.
Before purchasing 2-(thiophen-2-yl)phenol CAS 106584-13-8, I suggest reviewing the certificate of analysis, analytical method, appearance description, water or residual solvent information where relevant, and the known impurity profile. The certificate should be traceable to the supplied batch and should clearly identify the material. If a buyer needs NMR, MS, HPLC, GC, or other data, that request should be stated before quotation.
Storage and transport information also deserve attention. The buyer should confirm the recommended container, temperature range, light exposure guidance, and any restrictions related to shipping classification. These details can affect both laboratory handling and the reliability of the material after delivery.
I recommend starting with identity and specification alignment rather than price alone. A capable supplier should be able to discuss the requested CAS number, intended use, assay expectations, packaging, documentation, and target quantity in clear technical terms. If the supplier cannot distinguish between a research intermediate and a finished drug substance, that may indicate a mismatch with the project’s needs.
Buyers should compare minimum order quantity, quotation validity, lead time, payment terms, packaging, shipping route, and availability of repeat supply. For development work, I also recommend asking whether the same specification can be maintained across future batches. No supplier should promise an exact delivery schedule without confirming production status, quantity, logistics, and destination requirements.
Maison Chemical supplies specialty chemicals and pharmaceutical intermediates for customers involved in research, development, and commercial sourcing. For 2-(thiophen-2-yl)phenol CAS 106584-13-8, I can help organize a quotation around the buyer’s required quantity, target specification, packaging preference, and destination. I can also help clarify which documents are needed for internal approval and technical review.
Our support is intended to make the sourcing process more practical. Instead of treating every inquiry as a standard catalog request, I encourage buyers to provide the intended application, estimated annual demand, required assay, delivery location, and timeline. This information allows us to respond more accurately while avoiding unsupported assumptions about grade, availability, or regulatory suitability.
2-(thiophen-2-yl)phenol CAS 106584-13-8 may be a suitable intermediate when your route requires both a phenolic functionality and a thiophene-containing aromatic structure. Its value depends on the planned transformation, purity requirements, solvent and reaction conditions, and the quality of the final product you are developing. I recommend confirming the structure and batch specification before making a scale-up decision.
As a next step, send Maison Chemical your required quantity, target assay, preferred packaging, application stage, destination, and requested documents. I can then help assess the appropriate supply option and prepare a B2B quotation based on your actual requirements. This approach gives you a clearer basis for evaluating technical fit, cost, lead time, and long-term supply continuity.
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