What Is 4-(Hydroxymethyl)phenylboronic Acid CAS 59016-93-2? Uses, Properties, and Procurement Considerations
4-(Hydroxymethyl)phenylboronic acid, identified by CAS 59016-93-2, is an aromatic boronic acid building block containing both a boronic acid group and a hydroxymethyl group. Its molecular formula is commonly represented as C7H9BO3, with a calculated molecular weight of approximately 151.96 g/mol. I supply this compound through Maison Chemical for research, pharmaceutical, agrochemical, and advanced organic synthesis applications, subject to the buyer’s required specification and documentation.
The molecule is valuable because it combines two different reactive handles in one structure. The aryl boronic acid group can participate in palladium-catalyzed cross-coupling chemistry, while the hydroxymethyl group can support further protection, oxidation, substitution, or linker-construction steps. For procurement teams, the most important considerations are identity confirmation, assay, impurity profile, packaging, storage, documentation, and the supplier’s ability to provide a consistent batch-to-batch supply.
What Is 4-(Hydroxymethyl)phenylboronic Acid?
4-(Hydroxymethyl)phenylboronic acid is a para-substituted phenylboronic acid derivative. In practical terms, a phenyl ring carries a boronic acid functionality and a hydroxymethyl functionality positioned at the 4-position relative to each other. This structure makes the compound a useful intermediate when a synthesis requires controlled access to both aryl-coupling chemistry and an alcohol-derived functional group.
The compound is also known as a hydroxymethyl-substituted arylboronic acid in technical discussions. The CAS number, 59016-93-2, should be used together with the chemical name, molecular formula, and analytical data when creating purchasing specifications. A CAS number helps identify the intended substance, but it does not by itself define assay, water content, particle size, packaging, or suitability for a specific reaction.
Core Functions and Chemical Value
Aryl boronic acid functionality
The boronic acid group is commonly used as a coupling partner in Suzuki–Miyaura reactions with suitable aryl or heteroaryl halides and related electrophiles. The reaction conditions depend on the catalyst, base, solvent, temperature, substrate, and scale, so I recommend treating published reaction conditions as a starting point rather than a guaranteed process recipe. The boronic acid group may also be sensitive to reaction environment, moisture, and prolonged storage conditions.
Hydroxymethyl functionality
The hydroxymethyl group provides a primary alcohol that can be converted or protected according to the project design. Depending on the route, chemists may investigate oxidation to an aldehyde or carboxylic acid, ether or ester formation, or use of the alcohol as a point for attaching a linker. These transformations should be validated experimentally because selectivity can depend strongly on the protection strategy and on the compatibility of the boronic acid group with the selected reagents.
Common Application Scenarios
I see this type of intermediate used mainly in medicinal chemistry, pharmaceutical process research, and custom organic synthesis. It can support the preparation of biaryl compounds, functionalized aromatic intermediates, and molecules in which an alcohol-containing side chain must remain available for later derivatization. It may also be considered for linker development, probe synthesis, and research involving boron-containing recognition or binding motifs.
In discovery chemistry, the compound can help researchers introduce structural diversity at an aromatic position through cross-coupling. In process development, its value depends on reproducible reaction performance, impurity control, and the ability to scale handling safely. For commercial projects, I recommend confirming the intended downstream transformation before selecting a grade, because a material suitable for exploratory synthesis may require additional documentation or tighter controls for later-stage work.
Types and Material Options Buyers May Encounter
Suppliers may offer this material as a research-grade or synthesis-grade solid, with differences in assay limits, analytical documentation, packaging, and batch availability. The exact appearance, such as color or crystal form, should be confirmed from the current product specification rather than assumed from a generic catalog description. Different projects may also require different levels of documentation, including a certificate of analysis, analytical spectra, residual solvent information, or a safety data sheet.
For route development, a standard pack may be sufficient for initial experiments. For repeated manufacturing support, buyers should discuss larger-pack availability, packaging compatibility, retest policy, and the supplier’s ability to reserve or reproduce a specification. I can help evaluate these requirements before quotation so that the selected material aligns with both chemistry and supply planning.
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Key Specifications to Review
The first specification is identity. A buyer should verify CAS 59016-93-2, chemical name, molecular formula, and molecular weight of approximately 151.96 g/mol; for a theoretical 1.00 mmol charge, the corresponding mass is approximately 151.96 mg before accounting for assay or moisture correction. Identity testing may include techniques such as nuclear magnetic resonance spectroscopy, infrared spectroscopy, mass spectrometry, or chromatographic comparison, depending on the supplier’s documentation package.
The second specification is purity or assay, which should be stated with a defined analytical method. Buyers should also ask whether the reported value is chromatographic area percentage, assay by another method, or corrected for water and residual solvents. Additional relevant items can include water content, residual solvents, related substances, inorganic residues, lot number, manufacturing date, retest or review date, and recommended storage conditions.
Because boronic acids can show behavior influenced by moisture and storage history, I recommend requesting a current certificate of analysis for the offered lot. The certificate should be reviewed against the buyer’s internal acceptance criteria, especially when the compound is used in a sensitive coupling sequence. If the material will enter a regulated development program, documentation expectations should be agreed before purchase rather than after delivery.
Buyer Selection Factors
Match the material to the synthesis stage
For early route screening, practical availability and fit-for-purpose analytical data may be the main priorities. For process development, the buyer may need tighter impurity control, stable supply, reproducible packaging, and clear lot traceability. For regulated or customer-facing programs, the procurement package may need to include additional declarations and records that are not necessary for exploratory laboratory use.
Evaluate supply reliability
Price alone does not determine the total sourcing value of a specialty intermediate. A lower unit price may be offset by long lead times, inconsistent documentation, inadequate packaging, or an inability to repeat the same specification. I recommend comparing quoted quantity, lead time, available stock, production route or sourcing model where disclosable, quality documents, and communication response before approving a supplier.
Confirm handling expectations
The buyer should review the supplier’s safety data sheet and internal chemical hygiene procedures before opening or using the product. Handling controls should reflect the actual hazard classification, quantity, operation, and laboratory or production environment. I do not recommend inferring safe handling instructions solely from the chemical name; the current SDS and site-specific risk assessment should control the operation.
How Maison Chemical Supports Procurement
At Maison Chemical, I approach this product as a B2B sourcing requirement rather than only a catalog transaction. I can help buyers review the required CAS number, target quantity, assay expectation, packaging preference, documentation needs, and destination-market requirements before preparing a quotation. This approach reduces ambiguity when the same intermediate is being evaluated for both research and future scale-up.
Our support can include product identification, specification discussion, quotation coordination, document review, and shipment planning through the appropriate commercial process. Availability, minimum order quantity, lead time, and packaging should be confirmed for each inquiry because these factors may vary by batch, quantity, and destination. Buyers should provide their preferred specification and delivery timeline so that I can respond with a more relevant supply proposal.
Key Takeaways
- 4-(Hydroxymethyl)phenylboronic acid is an aromatic boronic acid intermediate with a second, primary alcohol functionality.
- Its CAS number is 59016-93-2, and its commonly represented molecular formula is C7H9BO3.
- The calculated molecular weight is approximately 151.96 g/mol, which is useful for reaction planning and purchasing calculations.
- Its main value is the combination of aryl cross-coupling potential and hydroxymethyl-based derivatization.
- Buyers should verify lot-specific identity, assay, impurity data, water or residual solvent information, packaging, and supply terms.
Conclusion: Is This the Right Intermediate for Your Project?
4-(Hydroxymethyl)phenylboronic acid CAS 59016-93-2 is a useful choice when a project requires a para-functionalized aryl boronic acid that also retains a hydroxymethyl group for subsequent chemistry. It is particularly relevant to medicinal chemistry, pharmaceutical intermediate development, and custom synthesis, although actual suitability must be confirmed through reaction testing and project-specific quality requirements. The compound’s identity and approximate molecular weight provide a clear starting point, but the offered lot specification determines whether it fits the intended application.
As the next step, I recommend preparing a short purchasing brief containing the required quantity, target assay, acceptable impurity limits, documentation list, packaging format, destination, and required delivery date. Send these details to Maison Chemical for a focused quotation and supply review. I can then help you determine whether the available material is appropriate for laboratory evaluation, process development, or a continuing B2B supply program.